Mouse Monoclonal Antibody to KSHV ORF45

Item#:

sAP-0016

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0016
Product Name	Mouse Monoclonal Antibody to KSHV ORF45
Target Molecle	KSHV ORF45
Aliases	ORF45
Species	KSHV
MW	N/A
Enterez GeneID	4961474
General Information	Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi¿s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman¿s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions
Immunogen	Purified recombinant fragment of KSHV ORF45 expressed in E. Coli.
Clone	MM2D4A5;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. James J et al. Proc. Natl. Acad. Sci Vol. 1996. 93, pp. 14862-14867.