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Mouse Monoclonal Antibody to P16 (Mouse and Human)
Item#:
sAP-0102
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0102
Product Name Mouse Monoclonal Antibody to P16 (Mouse and Human)
Target Molecle P16 (Mouse and Human)
Aliases P16
Species Human,Rat
MW N/A
Enterez GeneID 1029
General Information The progression of cells through the cell cycle is regulated by a family of protein kinases known as cyclin-dependent kinases (Cdks). The sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle. The cyclins function as differentially expressed positive regulators of Cdks. Negative regulators of the cycle include the p53-inducible 21 kDa WAF1/Cip1 protein designated p21, Kip1 p27 and p16. The complexes formed by Cdk4 and the D-type cyclins have been strongly implicated in the control of cell proliferation during the G1 phase. It has recently been shown that p16 binds to Cdk4 and inhibits the catalytic activity of the Cdk4/cyclin D complex. Moreover, the gene encoding p16 exhibits a high frequency of homozygous deletions and point mutations in established human tumor cell lines.
Immunogen Purified recombinant fragment of P16 expressed in E. Coli.
Clone MM2D9A12;
Isotype Mouse IgG2b
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. Holmgen, A. et al., Annu. Rev. Biochem. 54, 237-271 (1985). ; 2. Wollman, E. E. et al., J. Biol. Chem. 263, 15506-15512 (1988). ; 3. Sasada, T. et al., J. Toxicol. Sci. 21, 285-287 (1996). ;
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