Mouse Monoclonal Antibody to SHC1

Item#:

sAP-1038

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-1038
Product Name	Mouse Monoclonal Antibody to SHC1
Target Molecle	SHC1
Aliases	SHC; SHCA
Species	Human; Mouse;
MW	62.8kDa
Enterez GeneID	6464
General Information	This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
Immunogen	Purified recombinant fragment of human SHC1 (AA
Clone	MM2F7C7;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Mod Pathol. 2012 Dec;25(12)