Mouse Monoclonal anti-Human IL-15 Antibody

Item#:

xAP-0415

Size	Price	Quantity
100.0 ug	$420.00

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Product Overview

Catalog Number	xAP-0415
ID	Mouse Monoclonal anti-Human IL-15 Antibody
Antigen Description	Interleukin-15 (IL-15) was discovered in supernatant from simian kidney epithelial cell line CV-1/EBNA, as a soluble factor capable of supporting proliferation of the IL-2-dependent cell line, CTLL-2 (1). IL-15 is a regulatory cytokine that is produced by dendritic cells, epithelial cells, human stromal cell line (IMTLH), fibroblasts, and monocytes (2). It plays an important role in immune response and shares many functions with IL-2, for example, it stimulates the proliferation of activated T cells (1, 2), NK cells (3) and B cells, and it induces immunoglobulin synthesis by B cells stimulated by anti-IgM or CD40 ligand (4). In addition, IL-15 promotes the development of dendritic cells (5), activates human neutrophils (6, 7) and induces the production of proinflammatory cytokines from macrophages (8). IL-15 acts as a bridge between innate and adaptive immunity because of its diverse roles in the immune system. IL-15 binds to heterotrimeric receptors composed of IL-15Ra, IL-15Rß, and IL-15R¿c. IL-15 shares with IL-2 the receptor chains ß and ¿c. IL-15 is normally not secreted in soluble form but is held on the cell surface bound to a unique receptor, IL-15Ra, especially on dendritic cells. Cell-bound IL-15 then is presented in trans to T cells and NK cells and is recognized by the ¿c receptor on these cells; such recognition maintains cell survival and intermittent proliferation (9).
Size	100ug
Immunogen	E. coli - expressed, recombinant human IL-15
Clone	#BH1509
Antibody Isotype	Mouse IgG1
Host Species	Mouse
Preparation	The antibody was purified by affinity chromatography.
Formulation	The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application	ELISA Capture
Storage & Handling	Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

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